Matthew Lutchko Staff Writer, Dartmouth College Envelope Writer Bio My name is Matthew Lutchko and I’m a student at Dartmouth College studying biology and mathematics; someday I would appreciate the opportunity to attend graduate school. Outside Dartmouth Undergraduate Journal of Science, I enjoy tutoring calculus, doing research in the Department of Mathematics/ at Geisel School …
Latest Articles Previous Next Biology Like Owls, These Tiny Desert Dinosaurs Hunted in the Dark Biology UV-Vis Spectroscopy: A Step in the Light Direction Biology PCR: Captivation Through Replication Load More The NCJS Community Featured Staff Writers Biology Inactivation of Type I Interferon Necessary for Myeloid-Derived Suppressor Cells Matthew Lutchko / Dartmouth College / April …
Figure 1: IFNγ (purple, bottom) is one kind of interferon, which are proteins that are key in activating cells vital to the immune response. Upon inhibition of its pathway, by mechanisms like those to be described, activation of those cells fails and immunosuppressive conditions result Source: Wikimedia Commons Interferons are a class of molecules involved …
Inactivation of Type I Interferon Necessary for Myeloid-Derived Suppressor Cells Read More »
Figure 1: Smear preparation of bone marrow from a patient with multiple myeloma, the cancer of plasma cells Source: Wikimedia Commons Activated B lymphocytes, or plasma cells, are the only cells capable of secreting antibodies and thus play a critical role in mediating immune response to pathogens (D’Souza & Bhattacharya, 2019). The production of an …
Figure 1: The image is taken from an elderly woman who has a type of acute myeloid leukemia in which the accumulation of immature blood-forming cells (purple) interferes with the production of normal white blood cells (pink) Source: Wikimedia Commons Leukemia is a type of blood cancer generally characterized by the suppression of proper function …
Bispecific Antibody Recruits Vγ9+ γδ T cells for Leukemia Treatment Read More »
Figure 1: T cells (green, blue, and red) surround and prepare to kill a cancer cell (green and blue). Vesicles (shown in red) in the T cells contain perforin and granzymes, proteins that orchestrate the killing of target cells. This process of targeted cell destruction is compromised when mitochondria are rendered defective by excessive antigen …
Defective Mitochondria Lead to Exhausted T Cells in the Tumor Microenvironment Read More »
Figure 1: The bottom arrow points to an autophagic vesicle engulfing and beginning to degrade the mitochondria (indicated by the arrowhead on the left) in addition to other cytoplasmic material Source: Wikimedia Commons Autophagy is an important process by which cells degrade and recycle damaged or unnecessary components (Rees, 2020). Currently, autophagy is a key …
Figure 1: Extracellular deposits of amyloid-beta proteins as seen in Alzheimer’s Disease patients Source: Wikimedia Commons As of June 2020, Alzheimer’s Disease (AD) was the sixth most common cause of death in the United States, as well as the leading cause for the onset of dementia. Largely due to continuously increasing life expectancies, it is …
Exploring Possibilities for the Early Diagnosis of Alzheimer’s Disease Read More »
This page is a historical record of past and present ICJS writers and writing projects From the Fall of 2020 to the Spring of 2022, ICJS writing revolved around the work of individual staff writers writing solo articles. Each ICJS staff writer is listed below and a page with their individual work is linked. Since …